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Detailed Explanation of the Functions of Gamma-Aminobutyric Acid (GABA)


Abstract

Detailed Explanation of the Functions of Gamma-Aminobutyric Acid (GABA)

The role of gamma-aminobutyric acid

1. Calming the nerves and anti-anxiety. Medical experts have proven that gamma-aminobutyric acid is an inhibitory neurotransmitter in the central nervous system and one of the most important neurotransmitters in brain tissue. Its function is to reduce neuronal activity and prevent overheating of nerve cells. Gamma-aminobutyric acid can bind to and activate brain receptors that are anti-anxiety, then work in conjunction with other substances to prevent anxiety-related information from reaching the brain's directive center.


2. Lowering blood pressure. Gamma-aminobutyric acid can act on the vascular motor center of the spinal cord, effectively promoting vasodilation to achieve the goal of lowering blood pressure. It has been reported that the effective antihypertensive component in traditional Chinese medicine, such as Astragalus, is gamma-aminobutyric acid.

3. Treating diseases. In 1997, research by Seitaro Daikuma indicated that gamma-aminobutyric acid is related to the formation of certain diseases. Patients with Parkinson's disease have lower concentrations of gamma-aminobutyric acid in their spinal cord, and patients with epilepsy also have lower concentrations of gamma-aminobutyric acid in their spinal fluid than normal levels.


Research conducted by Osaka University Medical School in Japan showed that gamma-aminobutyric acid has a significant improvement effect on Kuppeman syndrome. Additionally, the reduction of gamma-aminobutyric acid in neural tissue is also related to the formation of neurodegeneration in conditions such as Huntington's disease and Alzheimer's disease.

4. Reducing blood ammonia. Traditional Chinese medicine and Japanese researchers also believe that gamma-aminobutyric acid can inhibit the decarboxylation of glutamic acid and reduce blood ammonia. More glutamic acid combines with ammonia to produce urea, which is excreted from the body to alleviate ammonia toxicity and improve liver function.


Ingesting gamma-aminobutyric acid can increase the activity of glucose-6-phosphatase, making brain cells active, promoting brain tissue metabolism, restoring brain cell function, and improving neural function.

5. Enhancing brain vitality. Gamma-aminobutyric acid can enter the tricarboxylic acid cycle in the brain, promoting brain cell metabolism, while increasing the activity of glucose-6-phosphatase during glucose metabolism, increasing the production of acetylcholine, expanding blood vessels, increasing blood flow, and reducing blood ammonia, thereby promoting brain metabolism and restoring brain cell function.

6. Promoting ethanol metabolism. In a study involving alcoholics, taking gamma-aminobutyric acid and drinking 60ml of whiskey, blood was collected to measure the concentrations of ethanol and acetaldehyde in the blood. It was found that the latter's concentration was significantly lower than that of the control group.