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Product description

Dezhou Jinmao Chemical Co., Ltd.

Effective substance content: 99 (%)

Model: nwsw-03

Category: Amino Acids

Brand: Can Be Biological

Main use: Anti-stress To romote Growth

Product Specifications: 25 kg

4-aminobutyric acid, aminobutyric acid, pipecolic acid, GABA
【Physical and Chemical Properties】
White or off-white crystalline powder: slightly odorous, slightly bitter; easily soluble in water; content ≥99%
【product manual】
Gamma-aminobutyric acid (GABA), also known as aminobutyric acid, belongs to amino acid derivatives. It is a non-protein amino acid that acts as a nerve calmer in animals. It is mainly derived from glutamic acid through decarboxylation in animals. GABA is a central nerve sedative. Studies have shown that it has the effects of stabilization, anti-convulsions, lowering blood pressure, improving brain vitality, nourishing nerve cells, promoting growth hormone secretion, and protecting liver and kidney. As a new feed additive, γ-aminobutyric acid has the effects of resisting heat stress, promoting growth, and improving production performance for livestock and poultry, with significant effects and high safety.
1. Anti-stress: γ-aminobutyric acid is a strong nerve-suppressing amino acid, has the physiological effects of sedation, hypnosis, anti-convulsions, and lowering blood pressure. Effectively prevent and treat stress syndromes such as irritability, tail biting, fighting, feather pecking and anal pecking of livestock and poultry.
2. Promote growth: promote the secretion of growth hormone and promote growth.
3. Improve feed intake: enhance appetite, speed up digestion and absorption of feed nutrients, eliminate picky eating and anorexia of livestock and poultry, and increase daily gain.
4. Improve animal blood circulation function, improve livestock and poultry immunity and disease resistance, and make livestock and poultry produce better resistance to living environment.
【Scope of application】
Suitable for feeding animals such as pigs, poultry, cattle, fish and shrimp in different growth periods
【Add method】
Recommended amount

Add Object

Suckling Piglet

Medium Pig

big Pig


Raw Material Addition





The product is easy to absorb moisture and agglomerate, please keep it in a sealed, cool and dry place.
Packing specification: 25 kg / drum; paper drum lined with double-layer plastic bags, sealed and stored, or packed according to customer requirements.
【Shelf life】
Storage: shading, sealed and kept in a dark place.
Validity period: 24
4-aminobutyric acid (γ-aminobutyric acid)
4-Aminobutyric acid is referred to as GABA for short, and its character is flaky or needle-like crystal. Widely distributed in animals and plants. The seeds, rhizomes, and tissue fluids of plants such as legumes, ginsengs, and Chinese herbal medicines all contain 4-aminobutyric acid; in animals, 4-aminobutyric acid is almost exclusively found in nerve tissue, and the content of brain tissue is about 0.1-0.6mg / g tissue, immunological studies have shown that the highest concentration area is the substantia nigra in the brain.
As a chemical substance, GABA was synthesized as early as 1883. In 1950, it was found that the concentration of GABA in the normal brain of mammals is very high, but the physiological significance is unknown. Subsequently, someone extracted an extract from the bovine brain that inhibited the production of impulse in the crawfish stretch sensory neurons. It was found to have anti-acetylcholine and contractile effects on the ileum of guinea pigs and rabbits, and proved that the extract had an inhibitory effect. The component of action is GABA. Segal SA and others also confirmed that GABA has a general inhibitory effect on the central nervous system of mammals. Injecting GABA separated by ion electrophoresis into the neurons around the cross sulcus of the cat cortex can cause hyperpolarization of the neurons, and its potential and stimulation of the cortex The inhibitory potentials generated by the surface synapses were the same, and it was found that the GABA content in the fourth ventricle perfusate increased three-fold when electrical stimulation of Pu's cerebellar Pus cells was performed, so it is speculated that the chemical transmitter released by Pus neurons is GABA.
Physicochemical properties
Leaflet crystals (methanol-ether), needle crystals (water-ethanol), melting point 202 ° C (decomposed under rapid heating). At 25 ℃, the dissociation constants are Ka3.7 × 10-11 and Kb1.7 × 10-10. It is easily soluble in water, slightly soluble in hot ethanol, and insoluble in other organic solvents. Decomposes above the melting temperature to form pyrrolidone and water. Appearance: white crystal or crystalline powder.
White flakes or needle-like crystals; slightly odorous, deliquescent; very soluble in water, slightly soluble in hot ethanol, insoluble in cold ethanol, ether and benzene; decomposition point is 202 ° C; LD50 (rat, abdominal cavity) 5400mg / kg.
Gamma-aminobutyric acid is a very important inhibitory neurotransmitter in the central nervous system. It is a naturally occurring non-protein constituent amino acid with extremely important physiological functions. It can promote brain activation and improve brain health. , Anti-epilepsy, promote sleep, beauty and moisturizing, delay brain aging function, can supplement human inhibitory neurotransmitters, and has good blood pressure lowering effect. Promote kidney function improvement and protection. Inhibit fatty liver and obesity, activate liver function. Daily supplementation of a small amount of gamma-aminobutyric acid is beneficial to the relief of heart and brain blood pressure, and it can promote the balance of amino acid metabolism in the body and regulate immune function.
γ-aminobutyric acid is a strong neurosuppressive amino acid, with physiological effects of sedation, hypnosis, anticonvulsant, and blood pressure lowering. It is an inhibitory neurotransmitter (Inhibitory Neurotransmitter), which can inhibit animal activities and reduce energy consumption. GABA acts on GABA receptors in animal cells. GABA receptors are a chloride ion channel. The inhibitory or excitatory effect of GABA depends on the concentration of chloride ions inside and outside the cell membrane. After the GABA receptor is activated, it causes chloride ions The opening of the channel can increase the permeability of the cell membrane to chloride ions, allowing chloride ions to flow into nerve cells, causing hyperpolarization of the cell membrane, inhibiting neuronal cell excitation, and thereby reducing the amount of animal movement.
It is to reduce energy consumption by reducing the unconscious movement of animals, so as to achieve the purpose of promoting growth. γ-aminobutyric acid can promote the secretion of animal gastric juice and growth hormone, thereby increasing the growth rate and feed intake; it can excite the animal's feeding center, thereby increasing the feed intake.
It is a neurosuppressive product.
The physiological role of GABA
According to the current research, it is found that the physiological activity of GABA is mainly manifested in the following aspects:
(1) Sedative nerve and anti-anxiety. Medical scientists have proved that GABA is an inhibitory delivery substance of the central nervous system and one of the most important neurotransmitters in brain tissue. Its role is to reduce the activity of neurons and prevent nerve cells from overheating. GABA can bind and activate anti-anxiety brain receptors, and then cooperate with other substances to prevent anxiety-related information from reaching the brain indication center.
(2) Lower blood pressure. GABA can act on the vascular motor center of the spinal cord, effectively promote vasodilation and achieve the purpose of lowering blood pressure. According to reports, the effective antihypertensive component of traditional Chinese medicines such as astragalus is GABA.
(3) Treat diseases. In 1997, the research of Taiko Seirou showed that GABA is related to the formation of certain diseases. The concentration of GABA in the spinal cord of Parkinson's patients is lower, and the concentration of GABA in the spinal fluid of patients with epilepsy is also lower than normal. Research from the Osaka University School of Medicine in Japan shows that GABA has a significant improvement effect on Kupperman syndrome. In addition, the decrease of GABA in nerve tissue is also related to the formation of neurasthenia such as Huntington disease and Alzheimer's disease.
(4) Reduce blood ammonia. Chinese clinical medicine and Japanese researchers also believe that GABA can inhibit the decarboxylation reaction of glutamic acid and reduce blood ammonia. More glutamic acid combines with ammonia to produce urea and excreted from the body to relieve ammonia poisoning, thereby improving liver function. Ingestion of GABA can increase the activity of glucose phosphatase, make brain cells active, promote metabolism of brain tissue and restore brain cell function, and improve nerve function.
(5) Improve brain vitality. GABA can enter the tricarboxylic acid cycle in the brain, promote the metabolism of brain cells, and also increase the activity of glucose phosphatase during glucose metabolism, increase the production of acetylcholine, dilate blood vessels and increase blood flow, and reduce blood ammonia, promote brain metabolism, Restore brain cell function.
(6) Promote ethanol metabolism. Taking alcoholics as the object, blood was collected after taking GABA and then drinking 60ml of whiskey to measure the concentration of ethanol and acetaldehyde in the blood, and it was found that the concentration of the latter was significantly lower than that of the control group.
(7) Others. The latest research shows that GABA also has the functions of preventing skin aging, eliminating body odor, improving lipid metabolism, preventing arteriosclerosis and losing weight efficiently.
1. The synthesis method is prepared by ring opening of pyrrolidone. Digest the quicklime with distilled water into lime milk, pump it into the hydrolysis reactor, add pyrrolidone, raise the temperature to 125-130 ℃, keep the reaction pressure at 0.29MPa, and keep the reaction temperature for more than 10-14h. After the reaction, the temperature was lowered to 30 ° C, the output was filtered, and washed with distilled water. Add ammonium bicarbonate to the filtrate until no calcium ions are detected, then add activated carbon to decolorize at 80 ° C for 30min, filter at 60 ° C, wash with distilled water, combine the washing liquid with the filtrate, concentrate at 60 ° C under reduced pressure to precipitate crystals, add ethanol, After cooling, filtering and drying, the finished product is obtained with a yield of over 85%.
2. Fermentation method E. coli is used as strain. The fermentation medium is bran hydrolysate, corn steep liquor, peptone, magnesium sulfate and sodium chloride. Using soybean oil as antifoaming agent, the dosage is about 0.1%, and the fermentation unit is about 100 enzyme units / ml fermentation broth. In the refining process, the role of E. coli decarboxylase is used to convert L-glutamic acid into γ-aminobutyric acid, which can be dissociated into cations in aqueous solution. Strong acid styrene cation exchange resin is used for ion exchange. After elution, extraction, and then purified by resin, concentrated, crystallized, and dried to obtain the finished product.
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